Delivering genetic material to a stimulation site

A - Human Necessities – 61 – N

Patent

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A61N 1/05 (2006.01) C12N 15/63 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2539066

Delivery of genetic material to a stimulation site causes transgene expression by tissue at the stimulation site. In some embodiments, the delivered genetic material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tissue at the stimulation site. In some embodiments, the delivered genetic material causes expression of a metalloproteinase, an anti-inflammatory agent, or an immunosuppressant agent. Genetic material is delivered to the stimulation site via a stimulation lead. A stimulation lead for delivering genetic material to a stimulation site includes a chamber that contains a polymeric matrix. The matrix absorbs the genetic material and elutes the genetic material to the stimulation site.

L'acheminement de matériel génétique vers un site de stimulation permet d'obtenir une expression du transgène par le tissu au niveau du site de stimulation. Dans certains modes de réalisation, l'acheminement du matériel génétique entraîne une augmentation de l'expression de protéines, telles que les connexines, les jonctions lacunaires et les canaux ionique, ce qui augmente la conductivité du tissu au niveau du site de stimulation. Dans certains modes de réalisation, l'acheminement du matériel génétique entraîne l'expression d'une métalloprotéinase, d'un agent anti-inflammatoire ou d'un agent immunosuppresseur. Le matériel génétique est acheminé vers le site de stimulation par le biais d'un fil de stimulation. Un fil de stimulation destiné à l'acheminement de matériel génétique vers un site de stimulation comprend une chambre contenant une matrice polymérique. Cette matrice absorbe le matériel génétique et l'achemine vers le site de stimulation.

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