Delivery device for zero-order release of an active...

Details Delivery device for zero-order release of an active... Delivery device for zero-order release of an active...

A - Human Necessities

61

K

167/154, 167/3.1

A61K 9/22 (2006.01) A61K 9/66 (2006.01)

Patent

CA 1235654

ABSTRACT A delivery device for zero-order release of an active principle into a dissolution fluid includes a reservoir consisting of a solid matrix of a homogeneous mixture of a polymer material, at least a portion of the active prin- ciple and an additive soluble in the dissolution fluid with negative heat of solution, a coating on the solid matrix-type reservoir of a first, release rate-controlling insoluble membrane which modulates the active principle release according to the desired kinetics; and a second, protective membrane on the release rate-con- trolling membrane of a soluble polymer material.

487552

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