Delivery device having encapsulated excipients

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2148837

An asymmetric membrane, osmotic, delivery device having coated macroparticulate solubility modifiers. The device comprises a beneficial agent, an osmagent, a coated macroparticulate solubility modifier and an asymmetric membrane that surrounds the device components. The device is useful for dispensing a beneficial agent to an aqueous environment of use. The coated macroparticles modify the solubility of the beneficial agent so that its release can be controlled. The larger size of the solubility modifier macroparticles provides, for example. a longer release duration than would have been possible with a smaller size.

Dispositif pour administration osmotique, à membrane asymétrique, comportant des modificateurs de solubilité de type macroparticule enrobée. Le dispositif comprend un agent bienfaisant, un agent d'osmose, un modificateur de solubilité à base de macroparticules enrobées et une membrane asymétrique entourant les constituants du dispositif. Ce dernier est utile pour introduire un agent bienfaisant dans un milieu aqueux. Les macroparticules enrobées modifient la solubilité de l'agent bienfaisant, de façon à pouvoir en prolonger la libération. La grande taille des macroparticules modifiant la solubilité permet notamment d'obtenir une durée de libération plus longue que dans le cas de macroparticules de taille plus petite.

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