Delivery of antihistamines through an inhalation route

Details Delivery of antihistamines through an inhalation route Delivery of antihistamines through an inhalation route

A - Human Necessities

61

K

A61K 31/4545 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61M 11/00 (2006.01) A61M 15/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2447521

The present invention relates to the delivery of antihistamines through an inhalation route. Specifically, it relates to aerosols containing antihistamines that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antihistamine. In a method aspect of the present invention, an antihistamine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antihistamine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antihistamine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antihistamine; and, b) a device that forms an antihistamine containing aerosol from the composition, for inhalation by the mammal.

L'invention concerne l'administration d'antihistaminiques par inhalation. Elle concerne spécifiquement des aérosols contenant des antihistaminiques utilisés en thérapie par inhalation. Dans une réalisation de composition de l'invention, l'aérosol comprend des particules constituées d'au moins 5 pour cent en poids d'un antihistaminique. Dans une réalisation de procédé de l'invention, un antihistaminique est administré à un mammifère par inhalation. Le procédé consiste a) à chauffer une composition, comprenant au moins 5 pour cent en poids d'un antihistaminique, afin de former une vapeur et, b) à laisser refroidir cette vapeur, formant ainsi un aérosol de condensation, contenant des particules, qui est inhalé par le mammifère. Dans une réalisation de kit de l'invention, un kit destiné à administrer un antihistaminique à un mammifère par inhalation comprend a) une composition contenant au moins 5 pour cent en poids d'un antihistaminique, et b) un dispositif qui forme, à partir de la composition, un aérosol contenant un antihistaminique, aux fins d'inhalation par le mammifère.

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