Delivery of antipsychotics through an inhalation route

Details Delivery of antipsychotics through an inhalation route Delivery of antipsychotics through an inhalation route

A - Human Necessities

61

K

A61K 31/554 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 31/4515 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/519 (2006.01) A61K 31/541 (2006.01) A61K 31/5415 (2006.01) A61K 31/5513 (2006.01) A61K 31/553 (2006.01) A61P 25/18 (2006.01) A61M 11/00 (2006.01) A61M 15/00 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2446917

The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antipsychotic. In a method aspect of the present invention, an antipsychotic is delivered to a mammal through an inhalation route. The method comprises: a) Heating a composition, wherein the composition comprises at least 5 percent by weight of an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antipsychotic; and, b) a device that forms an antipsychotic containing aerosol from the composition, for inhalation by the mammal.

La présente invention porte sur l'administration d'antipsychotiques par inhalation, et spécifiquement, sur des aérosols contenant des antipsychotiques qui sont utilisés dans des thérapies par inhalation. Selon une réalisation de cette composition, l'aérosol comprend des particules comprenant au moins 5 % en poids d'un antipsychotique. Selon un procédé de cette invention, un antipsychotique est administré à un mammifère par inhalation. Le procédé consiste à: a) chauffer une composition comprenant au moins 5 % en poids d'un antipsychotique de façon à former de la vapeur; et, b) laisser refroidir la vapeur de sorte que se forme un aérosol de condensation comprenant des particules qui sont inhalées par le mammifère. Selon une réalisation, le kit de cette invention est utilisé pour administrer un antipsychotique par inhalation à un mammifère. Ce kit comprend: a) une composition comprenant au moins 5 % en poids d'un antipsychotique; et b) un dispositif qui forme un aérosol contenant un antipsychotique à partir de la composition et destiné à être inhalé par le mammifère.

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