Delivery of biologically active polypeptides

Details Delivery of biologically active polypeptides Delivery of biologically active polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/74 (2006.01) A61K 35/74 (2006.01) A61K 39/00 (2006.01) A61K 39/08 (2006.01) A61K 39/116 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2234941

The present invention relates to a use of non-invasive or non--pathogenic bacterium for delivering a polypeptide to a subject in need thereof, especially a Gram-positive bacterium, which expresses said polypeptide in situ. The invention further relates to pharmaceutical formulations comprising said bacterium and to methods for producing the pharmaceutical formulations.

Dans la présente invention, on divulgue l'utilisation d'une bactérie non pathogène ou non invasive pour administrer un polypeptide à un sujet qui en a le besoin, en particulier une bactérie Gram positive qui exprime ledit polypeptide in situ. On divulgue aussi des formulations pharmaceutiques comportant ladite bactérie et des méthodes pour les produire.

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