Delivery of compounds for the treatment of migraine through...

Details Delivery of compounds for the treatment of migraine through... Delivery of compounds for the treatment of migraine through...

A - Human Necessities

61

K

A61K 31/454 (2006.01) A61K 9/72 (2006.01) A61K 31/167 (2006.01) A61K 31/4045 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61M 11/00 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2447099

The present invention relates to the delivery of a migraine headache drug through an inhalation route. Specifically, it relates to aerosols containing a migraine headache drug that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of a migraine headache drug. In a method aspect of the present invention, a migraine headache drug is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of a migraine headache drug, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol compressing particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering a migraine headache drug through an inhalation route to a mammal is provided which comprises: a) a composition compressing at least 5 percent by weight of a migraine headache drug; and, b) a device that forms a migraine headache drug containing aerosol from the composition, for inhalation by the mammal.

L'invention concerne l'administration par voie pulmonaire d'un médicament contre les céphalées migraineuses. L'invention concerne en particulier des aérosols contenant un médicament contre les céphalées migraineuses, utilisés dans l'inhalothérapie. Selon un aspect de composition de la présente invention, l'aérosol comprend des particules contenant au moins 5 % en poids d'un médicament contre les céphalées migraineuses. Selon un aspect de procédé de l'invention, un médicament contre les céphalées migraineuses est administré à un mammifère par voie pulmonaire. Ce procédé consiste: a) à chauffer une composition, cette composition contenant au moins 5 % en poids d'un médicament contre les céphalées migraineuses, pour former une vapeur; et b) à permettre à cette vapeur de refroidir, ce qui forme un aérosol à condensation contenant des particules, qui est inhalé par le mammifère. L'invention concerne encore un kit destiné à administrer un médicament contre les céphalées migraineuses à un mammifère par voie pulmonaire, ce kit comprenant: a) une composition contenant au moins 5 % en poids d'un médicament contre les céphalées migraineuses; et b) un dispositif formant un aérosol de médicament contre les céphalées migraineuses à partir de ladite composition, destiné à être inhalé par le mammifère.

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