A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 39/085 (2006.01) A61K 39/106 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01) A61K 39/385 (2006.01)
Patent
CA 2319599
Compositions of HBsAg particles having biologically active molecules contained in the particles, and methods of their use, e.g. in stimulating enhanced immune responses, are described. Antigenic peptides contained in HBsAg particles were found to produce a CTL response where none was elicited by the peptide alone. Encapsulation of immunostimulating molecules, such as cytokines, greatly enhanced the CTL response evoked by the HBsAg particles themselves.
Compositions de particules d'antigène de surface de l'hépatite B (HBsAg) contenant des molécules biologiquement actives, et procédés d'utilisation desdites compositions, par ex. pour stimuler une réponse immunitaire accrue. On a découvert que des peptides antigéniques contenus dans les particules de HBsAg produisent une réponse des lymphocytes T cytotoxiques tandis que le polypeptide seul n'en provoque aucune. L'enrobage de molécules immunostimulantes, telles que les cytokines, favorise énormément la réponse des lymphocytes T cytotoxiques provoquée par les particules HBsAg elles-mêmes.
Barenholz Yechezkel
Diminsky Dvorah
Reimann Jorg
Schirmbeck Reinhold
Gowling Lafleur Henderson Llp
Reimann Jorg
Yissum Research Development Company Of The Hebrew University Of
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