Delivery of nanoparticles and/or agents to cells

Details Delivery of nanoparticles and/or agents to cells Delivery of nanoparticles and/or agents to cells

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2671850

The present invention provides systems, methods, and compositions for targeted delivery of nanoparticles and/or agents to tissues, cells, and/or subcellular locales. In general, compositions comprise a nanoparticle (e.g. quantum dot, polymeric particle, etc.), at least one modulating entity (such as a targeting moiety, transfection reagent, protective entity, etc.), and at least one agent to be delivered (e.g. therapeutic, prophylactic, and/or diagnostic agent). The present invention provides methods of making and using nanoparticle entities in accordance with the present invention.

La présente invention concerne des systèmes, des procédés, et des compositions permettant l'administration ciblée de nanoparticules et/ou d'agents à des tissus, des cellules, et/ou des niches sous-cellulaires. D'une manière générale, les compositions renferment une nanoparticule (par exemple, un point quantique, une particule polymérique, entre autres), au moins une entité modulatrice (telle qu'un groupement de ciblage, un réactif de transfection, une entité de protection, entre autres), et au moins un agent destiné à être administré (par exemple, un agent thérapeutique, prophylactique, et/ou diagnostique). La présente invention porte sur des procédés permettant de fabriquer et d'utiliser des entités nanoparticulaires conformément à ses modes de réalisation.

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