A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2271006
Synthetic polymer-based carrier vehicles for delivery of nucleic acid material to target cells in biological systems are made by self-assembly of the nucleic acid with cationic polymer material so as to condense the nucleic acid and form a polyelectrolyte complex. This complex is then reacted with reactive hydrophilic polymer material which bonds to the complex forming a hydrophilic coating that stabilises the complex and provides an outer protective steric shield. These carrier vehicles can be useful in gene therapy.
La présente invention a trait à des véhicules porteurs à base de polymères synthétiques utilisés dans l'acheminement du matériau acide nucléique afin de cibler des cellules dans des systèmes biologiques. Ces véhicules sont réalisés par l'auto-assemblage de l'acide nucléique avec un matériau polymère cationique pour condenser l'acide nucléique et former un complexe polyélectrolyte. Ce complexe est ensuite mis à réagir avec un matériau polymère hydrophile réactif qui se lit audit complexe de manière à former un film hydrophile qui stabilise le complexe et fournit un écran stérique de protection extérieure. Lesdits véhicules porteurs peuvent être utiles en thérapie génique.
Schacht Etienne Honore
Seymour Leonard Charles William
Ulbrich Karel
Borden Ladner Gervais Llp
Hybrid Systems Limited
Schacht Etienne Honore
Seymour Leonard Charles William
Ulbrich Karel
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