Delivery of phosphoinositide polyphosphates into cells

Details Delivery of phosphoinositide polyphosphates into cells Delivery of phosphoinositide polyphosphates into cells

C - Chemistry, Metallurgy

07

H

C07H 15/226 (2006.01) A61K 31/7036 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) G01N 33/50 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2345532

A method for facilitating delivery of a phosphatidylinositol polyphosphate or derivative thereof into a eukaryotic cell is disclosed. The method includes forming a complex of the phosphatidylinositol polyphosphate or derivative with a polyamine, and then contacting the cell with the complex. Preferred polyamines include aminoglycosides, dendrimeric polyamines, and histones. Compositions of matter for use in the method are also described. A method for screening compounds for minimum toxicity to eukaryotic cells and maximum toxicity to bacterial cells is also disclosed. Also disclosed is a method for monitoring calcium flux in a cell.

Cette invention vise à faciliter l'administration d'un polyphosphate de phosphatidylinositol ou d'un dérivé de ce composé dans une cellule eucaryote. Le procédé consiste à former un complexe de polyphosphate de phosphatidylinositol ou d'un dérivé de ce composé avec une polyamine, puis à mettre la cellule en contact avec ce complexe. Comme polyamines, on utilise de préférence des aminoglycosides, des polyamines dendrimériques, et des histones. L'invention concerne également des compositions pouvant être utilisées avec ce procédé. Elle porte également sur la recherche systématique de composés qui présentent une toxicité minimum pour les cellules eucaryotes et une toxicité maximum pour les cellules de bactérie. De plus, l'invention concerne la surveillance du flux de calcium dans une cellule.

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