Delivery of physiological agents with in-situ gels...

A - Human Necessities – 61 – K

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A61K 47/36 (2006.01)

Patent

CA 2537290

In-situ gelling compositions for delivering pharmacologically active substances to the tissues, body fluids, and mucosal surfaces of animal patients in the form of liquids, solids and powders, comprising anionic polysaccharides and especially low methoxyl pectins as gelling agents, methods of preparation, and method of use of the in-situ gelling compositions for the delivery and sustained release of a physiologically active agent, and especially vaccine antigens, to the tissues and mucosal surfaces of an animal.

L'invention concerne des compositions gélifiantes in situ destinées à l'administration de substances pharmacologiquement actives dans des tissus, des fluides corporels et des muqueuses d'animaux, ces compositions se présentant sous forme de liquides, de solides et de poudres et comprenant des polysaccharides anioniques et en particulier des pectines faiblement méthoxylées comme agents gélifiants. L'invention concerne également des procédés de préparation et une méthode d'utilisation de ces compositions gélifiantes in situ pour l'administration et la libération prolongée d'un agent physiologiquement actif, et en particulier d'antigènes vaccinaux, dans les tissus et les muqueuses d'un animal.

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