C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) G01N 33/564 (2006.01) G01N 33/80 (2006.01)
Patent
CA 2144767
GPI-linked proteins are transferred, especially in vivo, from vertebrate carrier cells to cells of a target vertebrate tissue. For example, for purposes of xenogeneic transplantation, cells bearing complement inhibition factor(s) specific for the recipient spe- cies, e.g., genetically engineered, red blood cells, are incubated with transplantable cells of a second, discordant donor species un- til transfer of the factor(s) occurs, The transfer may occur in vivo or in vitro, and the factor-bearing cells may be normal cells of the recipient species, or genetically engineered cells of the donor species which express a gene encoding a complement inhibition factor(s) of the recipient species. The method is particularly useful in modifying pig organs for xenotransplantation into humans.
Byrne Guerard W.
Kooyman David Lee
Logan John Steele
Nextran Inc.
Smart & Biggar
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