Delivery of sirna by neutral lipid compositions

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/04 (2006.01)

Patent

CA 2605068

The present invention relates to the fields of molecular biology and drug delivery. In certain embodiments, the present invention provides methods for the delivery of a siNA (e.g., a siRNA) to a cell via a neutral (non-charged) liposome. These methods may be used to treat a disease, such as cancer.

La présente invention a trait au domaine de la biologie moléculaire et l'administration de médicaments. Dans certains modes de réalisation, la présente invention a trait à des procédés pour l'administration d'un acide nucléique court à interférence (siNA) (par exemple, un ARNsi) à une cellule par l'intermédiaire d'un liposome neutre (non chargé). Ces procédés peuvent être utilisés pour le traitement d'une maladie, telle que le cancer.

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