C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 38/44 (2006.01) A61K 39/08 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/33 (2006.01) C12N 9/02 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2349496
A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dismutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dismutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cells and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondria.
Composition destinée à l'apport aux cellules neuronales de superoxyde-dismutase liée par une séquence de liaison à un constituant ciblant des cellules neuronales qui comprend un premier domaine qui le lie à une cellule neuronale et un second domaine responsable de la translocation de la superoxyde-dismutase dans la cellule neuronale. Après la translocation, la séquence de liaison subit un clivage et libère ainsi la superoxyde-dismutase du domaine ciblant des cellules neuronales. L'utilisation de cette composition dans le traitement des lésions oxydatives des cellules neuronales ainsi que son ciblage par l'utilisation de séquences initiales mitochondriales sont également décrits. L'invention concerne également un polypeptide hybride contenant une superoxyde-dismutase bactérienne et une séquence ciblant les mitochondries humaines.
Hallis Bassam
Shone Clifford Charles
Silman Nigel
Sutton John Mark
Goudreau Gage Dubuc
Microbiological Research Authority
Syntaxin Limited
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