A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 38/50 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2210718
A process for treating a disease or disorder of a host by delivery of a therapeutic agent to the brain of the host, which comprises transducing endothelial cells of blood vessels located in the brain of a host in vivo with a vector including a polynucleotide encoding a therapeutic agent. The vector is administered intravascularly to the host, and the vector produces the therapeutic agent in the endothelial cells.
Procédé pour le traitement d'une maladie ou d'une affection d'un hôte par administration d'un agent thérapeutique au cerveau de l'hôte, ce qui comprend la transduction de cellules endothéliales de vaisseaux sanguins dans le cerveau de l'hôte in vivo avec un vecteur comprenant un polynucléotide codant pour un agent thérapeutique. Le vecteur est administré par voie intravasculaire à l'hôte, et le vecteur produit l'agent thérapeutique dans les cellules endothéliales.
Mcgarrity Gerard J.
Oldfield Edward H.
Ram Zvi
Genetic Therapy Inc.
Mcgarrity Gerard J.
Oldfield Edward H.
Ram Zvi
Smart & Biggar
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