Delivery of trefoil peptides

Details Delivery of trefoil peptides Delivery of trefoil peptides

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/22 (2006.01) C07K 14/575 (2006.01) C12N 1/21 (2006.01) C12N 15/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2377107

The present invention relates to a micro-organism, preferably a bacterial strain, preferably a non-pathogenic strain, preferably a non-invasive strain, preferably a food grade strain, preferably a gram-positive bacterial strain, delivering a trefoil peptide <i>in vivo</i>. Preferably said trefoil peptide is TFF1. The present invention further relates to a method for the delivery of trefoil peptide to the gastro-intestinal tract comprising the administration of such a bacterial strain. The present invention also relates to a pharmaceutical composition comprising a trefoil peptide delivering bacterium as well as methods of treatment of acute gastro-intestinal inflammatory diseases comprising administration of said transformed bacterial strains, particularly for treating acute colitis, including but not limited to acute flare-ups of Crohn's disease and ulcerative colitis in humans, as well as for treating gastro-intestinal disorders of a similar nature in other animal species.

L'invention concerne un micro-organisme, de préférence une souche bactérienne, de préférence une souche non pathogène, de préférence une souche non invasive, de préférence une souche alimentaire, de préférence une souche bactérienne Gram positif, de distribution d'un peptide en trèfle in vivo. Ledit peptide est de préférence un TFF1. L'invention concerne aussi un procédé de distribution de ce peptide en trèfle dans le conduit gastro-intestinal consistant à administrer une telle souche bactérienne. L'invention concerne encore une composition pharmaceutique comprenant un peptide en trèfle permettant la distribution d'une bactérie et des procédés de traitement de maladies inflammatoires gastro-intestinales aiguës consistant à administrer ces souches bactériennes transformées, particulièrement pour le traitement de colites aiguës, entre autres, des poussées actives aiguës de la maladie de Crohn et des colites ulcéreuses chez les humains ainsi que pour le traitement de troubles gastro-intestinaux de nature similaire chez d'autres espèces animales.

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