Delivery system and methods for gene therapy

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/715 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2398197

According to the present invention, there is provided a gene therapy material which includes a nucleic acid material and a carbohydrate wherein the carbohydrate preferably is a modified pectin. Also in accordance with the present invention, there is provided a gene therapy material including a nucleic acid material, a carbohydrate material associated with the nucleic acid material, and a protective coating disposed about the carbohydrate material. Also in accordance with the present invention, there is provided a method for treating a tumor of the type which has carbohydrate binding sites expressed on the surface thereof by providing a therapeutic material, incorporating the therapeutic material into a body of a modified pectin material so as to produce a therapeutic composition, and administering the therapeutic composition to a patient.

La présente invention concerne un matériau pour thérapie génique comprenant un matériau à base d'acide nucléique et un glucide, de préférence une pectine modifiée. L'invention concerne également un matériau pour thérapie génique comprenant un matériau à base d'acide nucléique, un matériau glucidique associé au matériau à base d'acide nucléique, et un revêtement protecteur disposé autour du matériau glucidique. De plus, l'invention concerne un traitement d'une tumeur à la surface de laquelle s'expriment des sites de liaison glucidique. A cet effet, on prend un matériau thérapeutique que l'on incorpore dans un corps d'un matériau à base de pectine modifiée de façon à produire une composition thérapeutique que l'on administre à un patient.

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