Delivery system for porcine somatotropin

Details Delivery system for porcine somatotropin Delivery system for porcine somatotropin

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 38/27 (2006.01) A61K 48/00 (2006.01) C12N 15/70 (2006.01) C12N 15/79 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2346799

An expression construct is disclosed which is useful for delivering an exogenous polypeptide (e.g. a growth hormone such as somatotropin) to a host. In one application of the invention, the expression construct is introduced into a non-host recombinant cell encapsulated in a semi-permeable membrane for implantation into the host. The semi-permeable membrane inhibits immune surveillance and cell rejection events so that non-host, highly expressing, recombinant cells can be used.

La présente invention concerne un produit de recombinaison d'expression utile dans l'administration d'un polypeptide exogène (par exemple, une hormone de croissance telle que la somatotropine) à un hôte. Dans une réalisation de l'invention, le produit de recombinaison d'expression est introduit dans une cellule de recombinaison non hôte, encapsulée dans une membrane semi-perméable destinée à être implantée dans l'hôte. La membrane semi-perméable inhibe la surveillance immunitaire et les événements de rejet de cellule de manière à pouvoir utiliser des cellules de recombinaison non hôtes, à expression élevée.

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