Delivery system for therapy comprising hollow seeds,...

A - Human Necessities – 61 – M

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Details

A61M 37/00 (2006.01) A61K 9/00 (2006.01) A61M 31/00 (2006.01) A61M 36/00 (2006.01)

Patent

CA 2383019

Hollow metal seeds are provided having a therapeutic agent encapsulated therein, e.g., a nucleic acid or cytokine, that diffuses out of the seeds via one or more holes disposed therein and is thereby delivered to target sites, e.g., tumor cells. These hollow metal seeds can be precisely delivered to target sites, e.g., within a tumor, preferably by use of stereotactic guidance, ultrasound, CT, or MRI.

L'invention concerne des grains creux métalliques renfermant un agent thérapeutique encapsulé, par exemple un acide nucléique ou une cytokine, diffusé hors des grains par un ou plusieurs orifices situés à l'intérieur puis administré à des sites cibles, par exemple des cellules tumorales. Ces grains creux métalliques peuvent être administrés de façon précise aux sites cibles, par exemple dans une tumeur, de préférence par guidage stéréotaxique, ultrasons, tomographie assistée par ordinateur (CT) ou IRM.

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