C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61K 49/08 (2006.01) A61K 49/14 (2006.01) A61K 49/22 (2006.01) A61K 51/08 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2602946
The invention relates relates to pharmaceutical compositions comprising a phosphorylcholine conjugate, or an antibiody preparation, for example a monoclonal antibody, with specificity to a phosphorylcholine conjugate, and the use of these compositions in the treatment or prevention of atherosclerosis, for example in the treatment, prevention or reduction of further progression of atherosclerosis. Furthermore, the invention also relates to the use of phoshorylcholine conjugates or said antibody preparation, for example monoclonal antibody to produce a pharmaceutical composition optionally with an adjuvant. Furthermore the invention relates to diagnosing the presence or absence of antibodies, for example IgM or IgG antibodies, related to increased or decreased risk of developing ischemic cardivascular diseases.
L'invention concerne le traitement et la prévention de l'athérosclérose et de maladies cardio-vasculaires associées à l'athérosclérose. La présente invention porte également sur des méthodes pour diagnostiquer l'athérosclérose et des maladies cardio-vasculaires associées à l'athérosclérose. Dans certains modes de réalisation, des systèmes et des procédés biologiques permettent d'administrer un agent thérapeutique ou un agent d'imagerie sur des lésions d'athérosclérose telles que des plaques vulnérables.
Burnett Mary Susan
Epstein Stephen E.
Mullins Martin A.
Georgetown University
Medstar Health Inc.
Smart & Biggar
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