A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/162, 167/199
A61K 9/50 (2006.01) A61K 9/16 (2006.01) A61K 9/52 (2006.01) A61K 31/40 (2006.01) A61K 47/42 (2006.01)
Patent
CA 1323305
Abstract of the Disclosure Methods are described for targeting the release of an active pharmacological agent in an animal by administering that agent encapsulated in proteinoid microspheres which are stable to the environment encountered from the point of introduction until they migrate to the targeted body organs, fluids or cells and are there unstable. Orally administered delivery systems for insulin, heparin and physostigmine utilize encapsulating microspheres which are predominantly of less than about 10 microns in diameter and pass readily through the stomach wall and which are made of an acidic proteinoid that is stable and unaffected by stomach enzymes and acid, but which releases the microencapsulated agent in pharmacologically active form in the near neutral blood stream. Basic proteinoid microspheres encapsulating a dopamine redox carrier system are administered in the lower gastrointestinal tract, where they are stable, and then enter the blood stream, where the encapsulated agent is similarly released.
554255
Rosen Robert
Steiner Solomon S.
Emisphere Technologies Inc.
Ridout & Maybee Llp
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