Delivery vehicles comprising stable lipid/nucleic acid...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/44 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2220950

Stable polynucleotide delivery vehicles (SPDVs) are described which incorporate a polynucleotide/cationic lipid complex as structural components of the SPDV. The subject SPDVs may optionally incorporate synthetic biodegradable amphipathic lipids, and suitable targeting agents.

L'invention a pour objet des véhicules d'apport de polynucléotides stables (SPDV) qui contiennent, comme éléments structuraux, un complexe polynucléotidique/lipides cationiques. Les SPDV de l'invention peuvent éventuellement comprendre des lipides amphipatiques biodégradables de synthèse, et des agents de ciblage adéquats.

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