Delivery vehicles for bioactive agents and uses thereof

Details Delivery vehicles for bioactive agents and uses thereof Delivery vehicles for bioactive agents and uses thereof

A - Human Necessities

61

K

167/163

A61K 9/107 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2306090

Compositions for transporting a bioactive agent across a biological membrane include the bioactive agent, an oil, an oil-immiscible compound and a noncationic surface active agent. The compositions may deliver the bioactive agent through a chemical microporulation mechanism, which allows transfer of the agent across both cellular, intracellular organelle, and nuclear membranes. Compositions for nucleic acid delivery include nucleic acid, oil, oil-immiscible compound, noncationic surface active agent and essentially no cationic lipid, or include nucleic acid, oil, oil-immiscible compound and two noncationic surface active agents. The nucleic acid may be hydrophobically- modified, and be in combination with an oil, an oil-immiscible compound and at least one surface active agent. The compositions may be used for gene delivery to a cell, as well as delivery of other therapeutic agent.

L'invention concerne des compositions de transport d'un agent bioactif à travers une membrane biologique, les compositions comprenant l'agent bioactif, une huile, un composé immiscible dans l'huile et un agent de surface non cationique. Les compositions peuvent fournir l'agent bioactif par un mécanisme de microporulation chimique permettant le transfert de l'agent à travers des membranes à organites cellulaires et intracellulaires et des membranes nucléaires. Des compositions de fourniture d'acide nucléique comprennent un acide nucléique, une huile, un composé immiscible dans l'huile, un agent de surface non cationique et essentiellement un lipide non cationique, ou alors un acide nucléique, une huile, un composé immiscible dans l'huile et deux agents de surface non cationiques. L'acide nucléique peut être à modification hydrophobe et peut être combiné à une huile, un composé immiscible dans l'huile et au moins un agent de surface. On peut utiliser les compositions pour une fourniture de gènes dans une cellule, ainsi que pour une fourniture d'autres agents thérapeutiques.

Affiliated with

Also associated with

Rating

Delivery vehicles for bioactive agents and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Delivery vehicles for bioactive agents and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Delivery vehicles for bioactive agents and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2090632