Delocalisation of stitch errors in the writing of gratings

Details Delocalisation of stitch errors in the writing of gratings Delocalisation of stitch errors in the writing of gratings

G - Physics

02

B

G02B 6/136 (2006.01) G02B 5/18 (2006.01) G02B 6/124 (2006.01)

Patent

CA 2238625

The invention relates to novel racemic and optically active trans apovincaminic acid ester derivatives of formula (I), wherein R means hydrogen or a group (a), wherein Z stands for C1-4 alkyl, optionally substituted aryl, aralkyl, heteroaryl or 14-eburnameninyl group; and n is an integer of 2, 3 or 4, as well as therapeutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for the preparation of the above compounds and compositions, and in addition, to a method of treatment. The novel compounds of formula (I) exhibit particularly antioxidant, antiischemic as well as antiamnesic effects and are useful for inhibiting lipid peroxidation and for protection from or treatment of ischemia and amnesia as well as for treating various degenerative neurological diseases, e.g. Alzheimer's disease.

L'invention porte sur de nouveaux dérivés d'ester d'acide apovincaminique, racémiques ou optiquement actifs, de formule (I), où R est un hydrogène ou un groupe (a), Z représente un alkyle C1-4, un groupe aralkyle, hétéroaryle, 14-éburnaméninyle ou aryle avec substitution facultative, et n est un entier de 2, 3 ou 4. L'invention porte aussi sur : des sels de ces dérivés, de qualité thérapeutique; des compositions pharmaceutiques contenant ces composés; une méthode pour préparer les composés et compositions précités; une méthode de traitement. Les nouveaux composés de formule (I) possèdent en particulier des propriétés antioxydantes, antiischémiques et anti-amnésiques; en outre, ils se révèlent utiles pour empêcher la peroxydation des lipides, pour prévenir ou traiter l'ischémie et l'amnésie, et pour traiter diverses maladies neurodégénératives, comme la maladie d'Alzheimer.

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