.delta.12,13-iso-taxol analogs, antineoplastic use and...

Details .delta.12,13-iso-taxol analogs, antineoplastic use and... .delta.12,13-iso-taxol analogs, antineoplastic use and...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/337 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2179176

This invention provides 7-deoxy-.DELTA.12,13-iso-taxol analogs of formula (I). The compounds of formula (I) are useful for the treatment of the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

La présente invention concerne des analogues du 7-désoxy-.DELTA.?12,13¿-iso-taxol correspondant à la formule générale (I). Les composés de la formule générale (I) conviennent particulièrement au traitement des mêmes cancers que ceux pour lesquels le taxol fait preuve d'efficacité, y compris le cancer de l'ovaire, le cancer du sein et les mélanomes malins, ainsi que le cancer du poumon, le cancer de l'estomac, le cancer du colon, l'épithélioma malpighien spino-cellulaire de la tête et du cou et la leucémie chez l'homme.

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