.delta.4-desaturase genes and uses thereof

Details .delta.4-desaturase genes and uses thereof .delta.4-desaturase genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A01H 5/00 (2006.01) A23D 9/00 (2006.01) A23K 1/16 (2006.01) A23L 1/164 (2006.01) A23L 1/187 (2006.01) A23L 1/30 (2006.01) A61K 31/20 (2006.01) C07C 53/00 (2006.01) C12N 1/20 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/00 (2006.01) C12N 15/82 (2006.01) C12P 7/64 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2446439

The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., ".DELTA.4- desaturase"). In particular, .DELTA.4-desaturase may be utilized, for example, in the conversion of adrenic acid to .omega.6-docosapentaenoic acid and in the conversion of .omega.3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

L'invention porte sur l'identification de gènes impliqués dans la désaturation d'acides gras poly-insaturés au niveau du carbone 4 (p. ex., <= 4-désaturase). L'invention porte plus particulièrement sur 4-désaturase pouvant être utilisée, par exemple, dans la conversion d'un acide adrénique en un acide 6-docosapentaénoïque et dans la conversion d'un acide 3-docosapentaénoïque en acide docosahéxaénoïque. Les acides gras poly-insaturés obtenus par l'utilisation de l'enzyme peuvent être ajoutés à des compositions pharmaceutiques, des compositions nutritionnelles, des aliments pour animaux, ainsi que d'autres produits, dont les cosmétiques.

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