Delta 6,7-taxols antineoplastic use and pharmaceutical...

Details Delta 6,7-taxols antineoplastic use and pharmaceutical... Delta 6,7-taxols antineoplastic use and pharmaceutical...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/33 (2006.01) A61K 31/695 (2006.01) C07D 263/04 (2006.01) C07D 263/06 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2161328

This invention provides 7-deoxy-.DELTA.6,7-taxol and 7-deoxy-.DELTA.6,7-taxol analogs of formula (I). The compounds of formula a) are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

L'invention concerne le 7-désoxy- DELTA <6,7>-taxol ainsi que des analogues de 7-désoxy- DELTA <6,7>-taxol de la formule (I). Les composés de la formule (I) sont utiles dans le traitement de cancers contre lesquels on a démontré que le taxol est actif, parmi lesquels les cancers des ovaires et du sein humains, ainsi que le mélanome malin, le cancer des poumons, le cancer de l'estomac, le cancer du côlon, les cancers de la tête et du cou, ainsi que la leucémie.

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