C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 38/43 (2006.01) C12N 9/02 (2006.01) C12N 15/81 (2006.01) C12P 7/64 (2006.01)
Patent
CA 2615902
The present invention is directed to an isolated delta-6 desaturase gene from Schizochytrium. It is further directed to the cloning of delta-6 desaturase derived from Schizochytrium in Yeast. The nucleic acid sequence and the amino acid sequences of the delta-6 desaturase are disclosed. Further disclosed are the constructs, vector comprising the gene encoding the enzyme delta-6 desaturase in functional combination with the heterologous regulatory sequences. The novel delta-6 desaturase can be used in a metabolic pathway to convert linoleic acid to gamma linolenic acid (omega-6 pathway). The invention provides the identification, isolation of these novel nucleic acids from Schizochytrium that encode the above-mentioned proteins. The invention specifically exemplifies recombinant yeast cells harboring the vector comprising the delta-6 desaturase gene and by the virtue of the enzyme produced shall be able to produce gamnia-linolenic acid.
La présente invention concerne un gène delta-6 desaturase isolé issu de Schizochytrium. Cette invention concerne aussi le clonage de delta-6 desaturase dérivé de Schizochytrium dans une levure. Cette invention concerne aussi la séquence d'acide nucléique et des séquences d'acides aminés de la delta-6 desaturase. Cette invention concerne aussi les construits, le vecteur comprenant le gène codant pour l'enzyme delta-6 desaturase en combinaison fonctionnelle avec les séquences régulatrices hétérologues. Cette nouvelle enzyme delta-6 desaturase peut être utilisée dans une voie métabolique pour transformer l'acide linoléique en acide linoléique gamma (voie oméga-6). Cette invention concerne l'identification, isolation de ces nouveaux acides nucléiques de Schizochytrium codant pour les protéines susmentionnées. Cette invention concerne spécifiquement des cellules de levure recombinantes accueillant le vecteur comprenant le gène delta-6 desaturase et grâce à cette enzyme produite, ce dernier sera capable de produire l'acide gamma-linoleique.
Avestha Gengraine Technologies Pvt Ltd.
Avesthagen Limited
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
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