.delta.9 - tetrahydrocannabinol derivatives

Details .delta.9 - tetrahydrocannabinol derivatives .delta.9 - tetrahydrocannabinol derivatives

C - Chemistry, Metallurgy

07

D

C07D 311/80 (2006.01)

Patent

CA 2677780

A compound of formula (I) wherein R is selected from (i) a 5 to 7 membered heterocyclic ring containing 1 to 3 heteroatoms independently selected from nitrogen, oxygen and sulfur, which is optionally substituted by one or more groups independently selected from halo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; (ii) (C1-C6)alkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; (iii) (C1-C6)alkyl substituted by (C3-C13)cycloalkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; and (iv) (C3-C13)cycloalkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1C6)alkoxy and phenyl.

L'invention porte sur un composé de formule (I) dans laquelle R est choisi parmi (i) un noyau hétérocyclique à 5 à 7 chaînons contenant 1 à 3 hétéroatomes choisis indépendamment parmi l'azote, l'oxygène et le soufre, qui est facultativement substitué par un ou plusieurs groupes choisis indépendamment parmi halo, CN, NO2, alkyle en C1-C6, alcoxy en C1-C6 et phényle ; (ii) alkyle en C1-C6, qui est facultativement substitué par un ou plusieurs substituants choisis chacun indépendamment parmi halo, oxo, CN, NO2, alkyle en C1-C6, alcoxy en C1-C6 et phényle : (iii) alkyle en C1-C6 substitué par cycloalkyle en C3-C13, qui est facultativement substitué par un ou plusieurs substituants choisis chacun indépendamment parmi halo, oxo, CN, NO2, alkyle en C1-C6, alcoxy en C1-C6 et phényle ; et (iv) cycloakyle en C3-C6, qui est facultativement substitué par un ou plusieurs substituants choisis chacun indépendamment parmi halo, oxo, CN, NO2, alkyle en C1-C6, alcoxy en C1-C6 et phényle.

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