C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2620835
The invention relates to the delta and epsilon crystal form of the methanesulfonic acidaddition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4- methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide (the compound of formula I, see below), certain processes for their preparation, pharmaceutical compositions containing these crystal forms, and their use in diagnostic methods or for the therapeutic treatment of warm-blooded animals, and their use as an intermediate or for the preparation of pharmaceutical preparations for use in diagnostic methods or for the therapeutic treatment of warm-blooded animals, especially humans.
L'invention concerne les formes cristallines delta et epsilon du sel d'addition d'acide méthanesulfonique de 4-(4-méthylpipérazin-1-ylméthyl)-N-[4-méthyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phényl]-benzamide (composé représenté par la formule I), certains procédés pour leur préparation, des compositions pharmaceutiques contenant ces formes cristallines, ainsi que leur utilisation dans des méthodes diagnostiques ou pour le traitement thérapeutique d'animaux à sang chaud, et leur utilisation comme produit intermédiaire ou pour la préparation de préparations pharmaceutiques destinées à des méthodes diagnostiques ou au traitement thérapeutique d'animaux à sang chaud, et notamment d'êtres humains.
Fetherstonhaugh & Co.
Novartis Ag
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