C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A01K 67/00 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12P 21/06 (2006.01) C12P 21/08 (2006.01) C12Q 1/00 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2333893
The present invention is directed to a Delta cleavage peptide and fragments, derivative and analogs thereof, and its encoding nucleic acids. The present invention is also directed to a soluble Delta peptide and fragments, derivative and analogs thereof, and its encoding nucleic acids. The present invention is also directed to protein complexes of Delta and Kuz. The present invention is also directed to methods for detecting or measuring Delta activation by observing or measuring Delta cleavage products that are indicative of Delta activation. The present invention is also directed to methods for detecting or measuring Kuz activation by observing or measuring Delta cleavage products that are indicative of Kuz activation. The present invention is also directed to methods for detecting a molecule that modulates Delta activation or Kuz function by observing or measuring a change in the amount of or pattern of Delta cleavage products. The present invention is based, at least in part, on the discovery that Delta in its active form, i.e., the form that mediates signal transduction and that binds Notch, is a soluble fragment consisting of the extracellular domain.
La présente invention concerne un peptide de clivage de Delta, des fragments, des dérivés et des analogues de ce dernier, et les acides nucléiques le codant. L'invention se rapporte également à un peptide soluble de Delta, à des fragments, des dérivés et des analogues de ce dernier, et aux acides nucléiques le codant. L'invention concerne aussi des complexes protéiniques de Delta et de Kuz. L'invention concerne des procédés permettant de détecter et de mesurer l'activation de Delta en observant et en mesurant les produits de clivage de Delta, qui indiquent une activation de Delta. L'invention concerne des procédés permettant de détecter et de mesurer l'activation de Kuz en observant et en mesurant les produits de clivage de Delta, qui indiquent une activation de Kuz. L'invention concerne également des procédés permettant de détecter une molécule qui module l'activation de Delta ou la fonction de Kuz en observant ou en mesurant une modification dans la quantité ou le motif des produits de clivage de Delta. La présente invention repose en partie sur la découverte que, sous sa forme active, c'est-à-dire la forme qui assure la médiation de la transduction du signal et qui se lie à Notch, Delta est un fragment soluble composé du domaine extracellulaire.
Artavanis-Tsakonas Spyridon
Qi Huilin
Rand Matthew D.
Osler Hoskin & Harcourt Llp
Yale University
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