C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/16 (2006.01) A61K 31/55 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2564369
The invention relates to the crystalline form .delta.d of ivabradine hydrochloride of formula (I): (see formula I) characterized by its powder X-ray diffraction data diagram. The invention also relates to the use of the crystalline form .delta.d of ivabradine hydrochloride as a medication with bradycardic properties or for the treatment and prevention of myocardial ischemia, the associated irregular heart action or heart failure.
L'invention concerne la forme cristalline .delta.d du chlorhydrate de l'ivabradine de formule (I): (voir formule I), HCl caractérisée par son diagramme de diffraction X sur poudre. L'invention vise également l'utilisation de forme cristalline .delta.d du chlorhydrate de l'ivabradine comme médicament ayant des propriétés bradycardisantes ou pour le traitement et la prévention d'ischémie myocardique, des troubles du rythme associés ou de l'insuffisance cardiaque.
Auguste Marie-Noelle
Damien Gerard
Horvath Stephane
Les Laboratoires Servier
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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