Delta ribozyme for rna cleavage

Details Delta ribozyme for rna cleavage Delta ribozyme for rna cleavage

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2230203

The present invention relates to an enzymatic ribonucleic acid molecule consisting in a ribonucleotide sequence having an RNA substrate-cleaving enzymatic activity to cleave a separate RNA substrate at a cleavage site, which comprises: a) an RNA substrate binding portion base pairing with the RNA substrate only 3' of the cleavage site in two consecutive RNA duplex having three Watson-Crick base pairs, wherein the two consecutive RNA duplex are separated by one pyrimidine forming a non-conventional Watson-Crick base pair with a purine of the ribozyme, and wherein said pyrimidine or said purine is involved in a tertiary interaction with a third nucleotide of the ribozyme; b) an RNA substrate with a first nucleotide located 5' of the cleavage site is selected for the group consisting of U, A and G, and the first four nucleotides located 5' of the cleavage site remain single-stranded; c) an enzymatic portion including part or all of the RNA substrate binding portion and having the enzymatic activity located 3' and/or 5' of the RNA substrate binding portion; whereby base pairing of the enzymatic ribonucleic acid molecule with the separate RNA substrate causes cleavage of the RNA substrate at the cleavage site.

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