A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/355 (2006.01) A61K 31/513 (2006.01) A61K 31/7068 (2006.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2653728
Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA- PAC A2 human pancreatic cancer cells xenografted in nude mice. Also disclosed are methods of testing the efficacy of potential chemotherapeutic agents by measuring their effect on surrogate endpoint biomarkers, such as Ki-67 and p27. Associated compounds are also disclosed.
L'invention concerne des procédés pour le traitement de troubles néoplasiques, tels que le cancer du pancréas, à l'aide de tocotriénols, à savoir le gamma-tocotriénol et le delta-tocotriénol. Les effets antitumorigènes de ces composés sont présentés à la fois in vitro et in vivo à l'aide de plusieurs lignées cellulaires humaines du cancer du pancréas et de cellules humaines du cancer du pancréas MIA-PAC A2 xénogreffées dans des souris nues. L'invention concerne également des procédés consistant à tester l'efficacité d'agents chimiothérapeutiques potentiels par mesure de leur effet sur des biomarqueurs de point final de substitution, tels que Ki-67 et p27. Des composés associés sont également divulgués.
Malafa Mokenge P.
Sebti Said M.
Finlayson & Singlehurst
University Of South Florida
LandOfFree
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