Demand-release bioactive composition for implantable medical...

Details Demand-release bioactive composition for implantable medical... Demand-release bioactive composition for implantable medical...

A - Human Necessities

61

L

A61L 31/16 (2006.01) A61L 27/54 (2006.01) A61N 1/05 (2006.01)

Patent

CA 2518374

A biostable polymeric substrate of an implantable medical device unit includes a demand-release bioactive composition including one or more bioactive agents covalently bound to surface-modifying end groups of the substrate. Certain cellular activities, in proximity to the polymeric substrate, release substances reacting with the end groups such that the end groups release the one or more bioactive agents, which modify the certain cellular activities.

L'invention concerne un substrat polymère biostable d'un dispositif médical implantable comprenant une composition bioactive à libération sur demande contenant un ou plusieurs agents bioactifs liée par covalence à des groupes terminaux à modification de surface du substrat. Certaines activités cellulaires, à proximité du substrat polymère, libèrent des substances qui réagissent avec les groupes terminaux de manière que ces groupes terminaux libèrent un ou plusieurs agents bioactifs, ce qui modifie certaines activités cellulaires.

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