C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/755 (2006.01) A61K 38/37 (2006.01) C12N 15/12 (2006.01) C12P 21/00 (2006.01) A01K 67/027 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2684834
There is provided in accordance with the practice of this invention a demannosylated Factor VIII, the immunogenicity of which is substantially decreased or abolished in Human. The modified factor VIII is disclosed together with the modified amino acid sequence, changed by at least one substitution. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory anti-FVIII antibodies.
L'invention porte sur un Facteur VIII démannosylé, dont l'immunogénicité est sensiblement diminuée ou éliminée chez l'homme. Le Facteur VIII modifié est décrit conjointement à la séquence d'acides aminés modifiée, changée par au moins une substitution. Le Facteur VIII modifié est utile pour les hémophiles, soit pour éviter soit pour prévenir l'action d'anticorps anti-FVIII inhibiteurs.
Bayry Jagaadeesh
Dasgupta Suryasarathi
Kaveri Srinivas
Lacroix Desmazes Sebastien
Sami Chtourou Abdessatar
Gowling Lafleur Henderson Llp
Institut National de La Sante Et de La Recherche Medicale-Inserm
Lfb Biotechnologies
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