Demethyl maytansinoids

C - Chemistry – Metallurgy – 12 – P

Patent

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195/89, 260/237.

C12P 17/14 (2006.01) C07D 498/16 (2006.01) C12P 17/18 (2006.01)

Patent

CA 1144096

Abstract of the Disclosure Novel demethylmaytansinoids representable by the formula: Image (wherein X is Cl or H; R1 is H or acyl group) are produced from maytansinoids by means of enzymic transformation. The demethylmaytansinoids are useful as antifungal, antiprotozoal or antitumor agents.

323717

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