C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/29 (2006.01) A01H 5/00 (2006.01) C07K 14/415 (2006.01) C07K 16/16 (2006.01) C07K 19/00 (2006.01) C12N 9/96 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12N 15/82 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2440358
Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating macromolecules such as proteins; fusion proteins including SPs; nucleic acid constructs encoding the fusion proteins; and their uses in a variety of methods and applications.
L'invention se rapporte à de nouvelles protéines homo-oligomériques, résistant à la protéase et stables face aux dénaturants, également appelées protéines stables (SP) et dont l'activité est semblable à celle de la chaperone ; à des procédés de fabrication et de purification des SP ; à des acides nucléiques codant les SP ; à des procédés d'isolation d'acides nucléiques codant les SP ; à des anticorps reconnaissant les SP ; à l'utilisation de SP afin de stabiliser, replier, réparer empêcher l'agrégation et la désagrégation de macromolécules telles que les protéines ; à des protéines de fusion comprenant les SP ; à des constructions d'acide nucléique codant les protéines de fusion ; et à leur utilisation dans différents procédés et différentes applications.
Alegrand Tal
Altman Arie
Pelah Dan
Shoseyov Oded
Wang Wangxia
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Yissum Research Development Company Of The Hebrew University In
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