Denatured collagen peptides and uses thereof

Details Denatured collagen peptides and uses thereof Denatured collagen peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 38/39 (2006.01) A61K 39/395 (2006.01) C07K 14/78 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2657948

The invention provides peptide antagonists, such as synthetic collagen peptides comprising a cryptic collagen epitope. The invention provides antibody antagonists, or functional fragments thereof, that preferentially bind to denatured extracellular matrix components comprising these cryptic epitopes. It additionally provides methods for using the antagonists for inhibiting angiogenesis, tumor metastasis, and other tumor developmental processes, including cell migration, cell adhesion, cell proliferation, and tumor growth and for treating angiogenesis-dependent conditions or collagen-dependent conditions. The application also provides for use of the antagonists as a vaccine for inducing an immune response, immune focusing and induction of antibody responses.

La présente invention concerne des antagonistes peptidiques, tels que des peptides de collagène synthétiques. L'invention concerne des antagonistes d'anticorps, ou des fragments fonctionnels de ceux-ci, qui se lient préférentiellement à des composants matriciels extracellulaires dénaturés. L'invention concerne également des procédés d'utilisation des antagonistes pour inhiber l'angiogenèse, les métastases tumorales, et d'autres processus de développement tumoral, y compris la migration cellulaire, l'adhérence cellulaire, la prolifération cellulaire, et la croissance tumorale, et concerne le traitement de pathologies dépendantes de l'angiogenèse ou de pathologies dépendantes du collagène. La présente demande concerne en outre l'utilisation des antagonistes en tant que vaccin destiné à induire une réponse immunitaire, à focaliser la réponse immunitaire et à induire des réponses d'anticorps.

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