A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 47/48 (2006.01) A61K 49/08 (2006.01) A61K 51/06 (2006.01) C08G 79/00 (2006.01)
Patent
CA 2187921
The invention provides a dendrimeric compound comprising a dendrimeric backbone moiety with linked thereto a plurality of diagnostically or therapeutically active moieties, characterised in that the molecular skeleton of said compound contains at least one biodegradable cleavage site such that on cleavage thereof said active moieties are released in renally excretable form.
L'invention se rapporte à un composé dendrimère comprenant une fraction de squelette dendrimère à laquelle est liée une pluralité de fractions diagnostiquement et thérapeutiquement actives. Ce composé se caractérise en ce que son squelette moléculaire contient au moins un site de clivage biodégradable de sorte que, lors du clivage, ces fractions actives soient libérées sous une forme pouvant être excrétée par voie rénale.
Campion Brian
Fellman Jere Douglas
Garrity Martha
Margerum Larry
Fetherstonhaugh & Co.
Nycomed Salutar Inc.
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