Dendrimeric polychelants

Details Dendrimeric polychelants Dendrimeric polychelants

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/18 (2006.01) C07B 59/00 (2006.01) C07D 255/02 (2006.01) C07D 257/02 (2006.01) C07F 5/00 (2006.01) C07F 15/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2120763

2120763 9306868 PCTABS00021 There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA residues, conjugated to an up to fifth generation dendrimer backbone molecule, e.g. a starburst dendrimer. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed molecule, e.g. a protein.

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