Dendritic cell co-stimulator molecules

Details Dendritic cell co-stimulator molecules Dendritic cell co-stimulator molecules

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2407680

A costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.

La présente invention concerne une nouvelle molécule de protéine co-stomulante, B7-DC, qui est un membre de la famille B7, un ADN codant pour cette molécule, des vecteurs d'expression comprenant cette protéine B7-DC d'ADN, des fragments, des protéines/polypeptides de fusion et d'autres dérivés fonctionnels et enfin des cellules transformées exprimant B7-DC, qui conviennent pour des compositions et des techniques de vaccin. Cette invention concerne aussi des compositions et des techniques permettant d'induire des réponses efficaces induites par un lymphocyte T qui peuvent être maîtrisées en vue de renforcer l'immunité contre les tumeurs et les virus.

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