Dendritic cell-derived growth factor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2280287

The present invention relates to a novel DCDGF protein which is a member of a novel family of growth factors of which the prototype is called Insect-Derived Growth Factor (IDGF). In particular, isolated nucleic acid molecules are provided encoding the human DCDGF protein. DCDGF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DCDGF activity. Also provided are diagnostic methods for diagnosing DiGeorge Syndrome and, particularly, immune system- related disorders and therapeutic methods for treating immune system-related disorders.

La présente invention concerne une nouvelle protéine appelée facteur de croissance dérivé de cellules dendritiques (DCDGF) qui est un membre d'une nouvelle famille de facteurs de croissance dont le prototype est appelé facteur de croissance dérivé d'insectes (IDGF). L'invention concerne en particulier des molécules d'acide nucléique isolées codant le DCDGF humain. Sont également décrits des polypeptides de DCDGF ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant de produire ces polypeptides. L'invention concerne en outre des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité du DCDGF. Sont également décrits des procédés diagnostiques permettant de diagnostiquer le syndrome de Di George et, en particulier, des troubles associés au système immunitaire, ainsi que des procédés thérapeutiques permettant de traiter des troubles associés au système immunitaire.

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