Dendritic cell vaccines for treating cancer made from...

Details Dendritic cell vaccines for treating cancer made from... Dendritic cell vaccines for treating cancer made from...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61P 35/00 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2504451

This disclosure provides a technology for making a dendritic cell vaccine suitable for high volume manufacturing and distribution. Human pluripotent stem cells are differentiated in a multi-step protocol to generate cell populations bearing a dendritic cell phenotype. The cells are loaded by pulsing with a specific tumor antigen, or by activation of an inducible transgene. The primed dendritic cells are powerful components of a vaccination strategy to elicit an immune response against tumor-associated antigens like telomerase. Vaccines and reagent combinations prepared according to this invention can be used on demand as off-the-shelf products for the treatment of cancer.

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