C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/18 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2195528
The present invention provides for a gene, designated as dmk, that encodes a novel tyrosine kinase receptor expressed in high levels in denervated muscle. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the dmk gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between Dmk and agents that initiate signal transduction through binding to Dmk.
L'invention concerne un gène, désigné sous l'appellation dmk, codant du nouveau récepteur de la tyrosine kinase exprimé à des niveaux élevés dans le muscle énervé. L'invention concerne également des systèmes d'analyse utiles pour détecter et/ou mesurer des ligands liant le produit génique de dmk. L'invention concerne encore des méthodes diagnostiques et thérapeutiques basées sur l'interaction entre Dmk et des agents initiant la transduction du signal par la liaison avec Dmk.
Rojas Eduardo A.
Valenzuela David M.
Osler Hoskin & Harcourt Llp
Regeneron Pharmaceuticals Inc.
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