Dengue chimeric viruses

Details Dengue chimeric viruses Dengue chimeric viruses

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 39/12 (2006.01) C07K 14/18 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2633005

The invention relates to Dengue chimeric viruses which are less prone to accumulate point mutations and genetic variations. In these Dengue chimeric viruses, the NS5 gene, which encodes polymerase, has been replaced by the corresponding NS5 sequence of a Yellow Fever virus.

L'invention concerne des virus chimériques de la Dengue qui sont moins enclins à accumuler des mutations ponctuelles et des variations génétiques. Dans ces virus chimériques de la Dengue, le gène NS5, codant pour la polymérase, a été remplacé par la séquence NS5 correspondante d'un virus de la fièvre jaune.

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