C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/10 (2006.01) A61K 39/12 (2006.01) A61K 39/42 (2006.01) C07K 14/18 (2006.01) C12N 15/13 (2006.01) G01N 33/573 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2739551
The invention relates to antibodies and antigen binding fragments thereof and to cocktails of antibodies and anti-gen binding fragments that neutralize dengue virus infection without contributing to antibody-dependent enhancement of dengue virus infection. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antigen binding fragments. In addition, the invention relates to the use of the antibodies, antigen binding fragments, and epitopes in screening methods as well as in the diagnosis and therapy of dengue virus infection.
La présente invention concerne des anticorps et leurs fragments de liaison à lantigène et des cocktails danticorps et des fragments de liaison à lantigène qui neutralisent linfection du virus de la dengue sans contribuer à lactivation dépendante danticorps dinfection du virus de la dengue. Linvention concerne également des lymphocytes B immortalisés qui produisentà de tels anticorps et fragments de liaison à lantigène et des épitopes qui sy lient. Linvention concerne en outre lutilisation des anticorps, des fragments de liaison à lantigène, et des épitopes dans des procédés de dépistage ainsi que dans le diagnostic et le traitement dinfection du virus de la dengue.
Institute For Research In Biomedicine
Mbm Intellectual Property Law Llp
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