A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/10 (2006.01) A61F 2/28 (2006.01) A61F 2/44 (2006.01) A61K 9/00 (2006.01) A61L 27/54 (2006.01) A61L 27/56 (2006.01) B22F 7/00 (2006.01) B28B 1/24 (2006.01) B28B 1/26 (2006.01) B28B 19/00 (2006.01) B28B 23/00 (2006.01) B29C 45/00 (2006.01) A61F 2/00 (2006.01) A61F 2/30 (2006.01) A61F 2/42 (2006.01) A61F 2/46 (2006.01) B29C 45/14 (2006.01)
Patent
CA 2447683
A combination dense/porous structure includes a porous element having an outer surface defining a shape having a bulk volume, the element includes a continuous framework having struts defining a plurality of interconnecting interstices throughout the bulk volume. The porous element has interconnecting interstices extending throughout the volume and opening through the surface. The combination dens/porous structure also includes a dense element formed from a material and having a sintered density of at least 95%, contacting at least a portion of the porous element; and an interconnection zone formed by the inter-penetration of the material forming the dense element into the porous element. The combination dense/porous structures are particularly useful as bone substitute materials and extended release delivery systems, preferable sustained release, for physiologically active agents. The interconnection zone can also be formed by a bonding phase that may or may not be the same material as the dense and/or porous element. A process for producing a combination dense/porous structure includes: providing a porous element; providing a dispersion comprising a ceramic or metal powder and a binder; contacting the dispersion with the porous element whereby the slip at least partially penetrates into at least a portion of the porous element to form an interconnection zone and a dense element formed from the dispersion and adjacent to the interconnection zone to form a dense/porous structure; treating the dense/porous structure to form a green dens/porous structure; and curing, drying, and/or heating the green dense/porous structure to form the combination dense/porous structure.
L'invention concerne une combinaison de structures denses/poreuses comprenant un ~l~ment poreux dont la surface ext~rieure d~finit un volume global. Ledit ~l~ment comprend une charpente continue comprenant une pluralit~ d'entretoises d~finissant une pluralit~ d'interstices d'interconnexion traversant ledit volume apparent. Cet ~l~ment possde des interstices d'interconnexion traversant le volume et une ouverture d~bouchant sur la surface. La combinaison de structures denses/poreuses comprend ~galement un ~l~ment dense form~ ~ partir d'un mat~riau, poss~dant une densit~ de frittage d'au moins 95%, et coop~rant avec au moins une partie dudit ~l~ment poreux ~l~ment; et une zone d'interconnexion form~e par interp~n~tration du mat~riau formant l'~l~ment dense dans l'~l~ment poreux. Cette combinaison est particulirement utilis~e comme mat~riau de substitut osseux et dans des systmes de distribution ~ lib~ration ~tendue, de pr~f~rence ~ lib~ration prolong~e, pour des agents physiologiquement actifs. La zone d'interconnexion peut ~galement Útre form~e ~ l'aide d'une phase de liaison qui peut Útre constitu~e ou non du mÚme mat~riau que l'~l~ment dense et/ou poreux. Un proc~d~ de production de combinaison de structure dense/poreuse consiste ~ fournir un ~l~ment poreux; ~ fournir une dispersion comprenant une poudre m~tallique ou de c~ramique et un liant; ~ mettre en contact la dispersion, l'~l~ment poreux. la suspension p~n~trant au moins partiellement dans au moins une partie de l'~l~ment poreux afin de former une zone d'interconnexion, et un ~l~ment dense form~ ~ partir de la dispersion et adjacent ~ ladite zone d'interconnexion afin de former une structure dense/poreuse; ~ traiter ladite structure dense/poreuse afin de former une structure dense/poreuse fra¹che; et ~ durcir, s~cher, et/ou chauffer ladite structure dense/poreuse fra¹che afin de former la combinaison de structure dense/poreuse.
Cassidy James J.
Heckendorf Bradley R.
Ko Ying
Norberg Brian L.
Cassidy James J.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Wright Medical Technology Inc.
LandOfFree
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