Dental products comprising bone growth enhancing peptide

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 8/64 (2006.01) A61K 9/00 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 19/08 (2006.01) A61Q 11/00 (2006.01)

Patent

CA 2417207

Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.

L'invention concerne des produits dentaires, tels que pâtes dentifrices, bain de bouche et fil dentaire. Ces produits sont améliorés en ce qu'ils comprennent un composé dissous, dispersé ou revêtu qui stimule la croissance osseuse. Les composés préférés sont des séquences peptidiques comprenant entre 10 et 50 acides aminés. Ces séquences sont caractérisées en ce qu'elles contiennent un motif de liaison d'intégrine tel qu'une séquence RGD et la quantité non utilisée d'acides aminés contiguë à ladite séquence dans une phosphoglycoprotéine extracellulaire matricielle. Les séquences peuvent être formulées afin d'être dispersées dans la pâte dentifrice ou un bain de bouche et administrées en vue de stimuler la croissance osseuse et dentaire. Lorsque les produits dentaires sont utilisés de façon répétée dans le temps, ils contribuent à une bonne santé dentaire.

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